Influência do fator de aprendizagem na análise perceptivo-auditiva / Learning factor influence on the perceptual-auditory analysis

RESUMO Objetivo Investigar o fator de aprendizagem durante uma tarefa perceptivo-auditiva para três grupos diferentes em uma tarefa não usual. Método 269 ouvintes, divididos em três grupos: 73 no grupo dos fonoaudiólogos especialistas em voz (GE), 84 no grupo dos fonoaudiólogos não especialistas em voz (GNE) e 112 no grupo leigo (GL), dos não fonoaudiólogos. Todos foram submetidos a uma sessão de escuta que incluiu 18 vozes humanas e 18 vozes sintetizadas com diferentes tipos e graus de desvio, mais 50% de repetição para avaliar a consistência intraindivíduo. A tarefa era classificar as vozes como humana ou sintetizada. Analisou-se o fator de aprendizagem pela comparação da porcentagem de erros do começo, primeiras 18 vozes, e do final, últimas 18 vozes, da sessão de escuta. Resultados O GE foi submetido ao fator de aprendizagem, apresentando menos erros no final da tarefa (25,5%), do que no começo (28,6%), com diferença estatística (p = 0,024). O GNE e o GL não apresentaram diferença da porcentagem de erros no começo e no final da tarefa (GNE começo = 36,5%; GNE final = 35,3%; GL começo = 38,3%; GL final = 37,7%). Conclusão O GE foi o único grupo que apresentou indícios evidentes do fator de aprendizagem. Parece que a experiência profissional influencia de modo positivo a análise perceptivo-auditiva, reforçando o impacto de um treinamento para se tornar um especialista em voz. Ainda, o especialista em voz parece estar mais preparado e mais suscetível a utilizar estratégias de aprendizagem para melhorar sua performance durante uma tarefa perceptivo-auditiva mesmo que pouco usual.

ABSTRACT Purpose To investigate the learning factor during a perceptual-auditory analysis of an unusual task in three different groups. Methods 269 listeners, divided into three groups: 73 voice specialists Speech Language Pathologists (EG), 84 voice specialists Speech Language Pathologists (NEG); and 112 non-speech pathologists in the Naive Group (NG). They all completed a listening session that included 18 synthesized and 18 human voices with different types and degrees of deviation (50% of repetition for intra-rater consistency analysis). The task was to classify the voices as human or synthesized. We analyzed the learning factor by comparing the initial error percentage, first 18 voices, with the final, last 18 voices. Results EG presented less error towards the end of the task (25.5%) than at the beginning (28.6%) with statistical difference (p = 0.024). The error percentage of the beginning and the end of the task did not differ for the NEG and the NG (NEG beginning = 36.5%, end = 35.3%; NG beginning = 38.3%, end = 37.7%). Conclusion The EG was the only group to present evidence of learning factor. Therefore, it seems that professional experience positively influences the perceptual-auditory analysis, which reinforces the impact of its training to become a voice specialist. Moreover, the voice specialists seem to be more prepared and more susceptible to use learning strategies to improve their performance during a perceptual-auditory analysis task, even if unusual.

Prevalencia y factores asociados con la filariosis por Mansonella ozzardi en 2 comunidades periurbanas de Iquitos, 2009 / Prevalence of filariasis by Mansonella ozzardi and associated factors among 2 suburban communities of Iquitos, 2009

Introducción: Tres casos de infección por Mansonella ozzardi (M. ozzardi) en muestras de malaria que provenían de 2 comunidades periurbanas de Iquitos (Perú) dieron la sospecha de transmisión local. El objetivo del estudio fue determinar la prevalencia y factores asociados con la filariosis por M. ozzardi en estas comunidades. Materiales y métodos: Se realizó un estudio transversal en las comunidades de Laguna Azul y La Unión en Iquitos. A todos los pobladores se les tomó una gota gruesa para la detección de M. ozzardi y se les realizó una encuesta epidemiológica. Se realizó colecta de larvas y mosquitos para identificación de potenciales vectores. Se calcularon los OR ajustados (ORa) usando regresión logística múltiple. Resultados: Se evaluaron a 433 personas; 58% fueron mujeres; la mediana de edad fue de 20 años; 58,2% fueron migrantes, 3,7% pescadores y 12,9% habían viajado por las cuencas del Alto anay. La prevalencia de M. ozzardi fue de 1,4% (6/433) y el más joven de los casos tuvo 31 años; se encontró asociación con ser pescador (ORa: 8,7; IC 95: 1,1-76,0) y con haber realizado viajes por la cuenca del Alto Nanay (ORa: 11,2; IC 95: 1,2-112,5). No se evidenció densidad significativa de vectores simúlidos o culicoides. Conclusión: Las comunidades estudiadas tuvieron una baja prevalencia de M. ozzardi y por la edad de los casos y los factores asociados encontrados se sospecha infección foránea a la zona de estudio, en especial en la cuenca del Alto Nanay.

Introduction: Three cases of M. ozzardi infection from 2 suburban communities in Iquitos, Peru, led to a suspicion of local transmission. The objective of the study was to determine the prevalence of filariasis by M. ozzardi and its associated factors among these communities. Materials and methods: A cross-sectional study was performed, as well as an epidemiological survey and a thick smear blood test. Larvae and mosquitoes were collected. The adjusted OR (aOR) using multiple logistic regression was calculated. Results: A total of 433 participants were enrolled; 58% were women. The prevalence of M. ozzardi was 1.4% and the associated factors included being a fisherman (aOR: 8.7; 95%CI: 1.1-76.0) and being on the Alto Nanay river (aOR: 11.2; 95%CI: 1.2-112.5). No significant evidence of simulidos or culicoides was found. Conclusion: The low prevalence of M. ozzardi found suggests a foreign infection, probably derived from the Alto Nanay river.

Proceso de construcción de la agenda nacional de investigación sobre Recursos Humanos en Salud (RHUS) en el Perú, 2011-2014 / Process of construction of the national research agenda on Human Resources in Health in Peru 2011 - 2014

La Autoridad Sanitaria Nacional del Perú, como parte del proceso de implementación de las prioridades nacionales de investigación en salud en el 2010, desarrolló el proceso de construcción de la agenda nacional de investigación sobre recursos humanos en salud (RHUS). En un escenario de desafíos técnico-políticos nacionales e internacionales y bajo un enfoque participativo de alcance nacional, con actores clave del sistema de salud, formación de RHUS y cooperantes vinculados con el tema, se establece una agenda socialmente consensuada. El proceso consta de tres fases: 1. Revisión nacional de evidencias e información relevante sobre RHUS; 2. Consulta a líderes de opinión y expertos temáticos y 3. Un espacio participativo (taller nacional) de deliberación, consenso y legitimación de la agenda. Finalmente se presenta la agenda compuesta por 30 temas de investigación sobre RHUS para ser desarrolladas en el período 2011-2014 y se plantean los retos y perspectivas para su implementación.

The National Health Authority of Peru, as part of the implementation of national priorities for health research in 2010 developed the process of building the national research agenda on health manpower (HM). In a scenario of technical challenges, national and international policy and under a nation-wide participatory approach with key stakeholders in the health system, training and aid HM linked to the subject, establishing a socially agreed agenda. Process consists of 3 phases: 1. National review of evidence and relevant information on RHUS, 2. Consultation with opinion leaders and subject experts, and 3. A collaborative space (national workshop) of deliberation, consensus and legitimacy of the agenda. Finally, we present the agenda consists of 30 research topics on health manpower, to be developed in the period 2011- 2014, and raises the challenges and prospects for implementation.

Efecto del levonorgestrel como anticonceptivo oral de emergencia en la ovulación, el endometrio y los espermatozoides / Effect of levonorgestrel in the ovulation, endometrium, and spermatozoa for emergency oral contraception

Existe amplia controversia acerca del mecanismo de acción del levonorgestrel como anticonceptivo oral de emergencia; numerosas organizaciones, tanto científicas como de la sociedad civil, muestran su disconformidad con su uso, debido a su posible acción como inductor de aborto. Con el objetivo de evaluar la evidencia científica disponible sobre los mecanismos de acción del levonorgestrel utilizado como anticonceptivo oral de emergencia (AOE), se realizó una revisión sistemática en las bases de datos Medline y Cochrane Library donde se encontró 444 artículos; después de revisar los resúmenes, se seleccionó 22 artículos, los cuales fueron evaluados a texto completo. Se encontró que el principal mecanismo de acción del levonorgestrel, a las dosis recomendadas como AOE, es la inhibición o retraso de la ovulación; no afecta a los espermatozoides en su capacidad de migración ni de penetración al óvulo. No se ha demostrado alteraciones morfológicas ni moleculares en el endometrio que puedan interferir con la implantación del huevo fecundado. No existe evidencia científica actual disponible que sustente que el uso de levonorgestrel como AOE sea abortivo.

There is wide controversy about the mechanism of action of the levonorgestrel used for emergency oral contraception, and many organizations, both scientific as well as from the civil society, show their discrepancy with its use, due to its possible action as an abortion-inducer. In order to evaluate the scientific evidence available on the mechanisms of action of the levonorgestrel used for emergency oral contraception (EOC), a systematic revision was performed in the Medline and Cochrane library databases. We found 444 articles. After reviewing the abstracts, we selected 22 articles, whose complete texts were evaluated. We found that the main mechanism of action of the levonorgestrel, given at the doses recommended for EOC, is the inhibition or retardation of the ovulation, it doesn't affect the spermatozoa in their migration or egg-penetration capacities. No morphological or molecular alterations in the endometrium that could interfere with the implantation of the fertilized egg have been demonstrated. There is no actual scientific evidence available supporting that the use of levonorgestrel for EOC is abortive.

Susceptibilidad de lutzomyia verrucarrum a piretroides en zonas endémicas de enfermedad de Carrión de Ancash / Pyrethroids susceptibility of Lutzmoyia verrucarum in endemic areas of Carrion disease from Ancash

La enfermedad de Carrión es una infección metaxénica endémica del Perú, el control vectorial de la Lutzomyia verrucarum con insecticidas es una de las formas más usadas para reducir su morbilidad. Se determinó la susceptibilidad de este vector a los piretroides más usados (cyflutrina, alfacipermetrina y deltametrina) en dos zonas endémicas altoandinas de Ancash (Llumpa: 3200 msnm y Maya: 2600 msnm), Perú en junio de 1999. Se expuso a 50 mosquitos por cada zona e insecticida usando la prueba de contacto para anophelinos modificada. Se encontró una mortalidad del 100 por ciento para cada piretroide ensayado. Si bien se demostró una susceptibilidad total de L. verrucarum es necesario implementar la vigilancia de la resistencia a insecticidas como se hace con otros vectores en el Perú.

Carrion disease is an endemic vector-borne infection of Peru, the vector control of the Lutzomyia verrucarum with insecticides is one of the most commonly used to reduce morbidity. It was determined the susceptibility of this vector to the most pyrethroids widely used (cyfluthrin, alfacypermethrin and deltamethrin) in two endemic areas of highlands from Ancash (Llumpa: 3200 and Maya: 2600 meters above sealevel), Peru in June 1999. Were exposed to 50 mosquitoes from each area and insecticide, using an anopheline contact test modified. Wefound a mortality rate of 100 per cent for each pyrethroid tested. While total susceptibility of L. verrucarum showed, is necessary the implement of surveillance to insecticides resistance as is done with other vectors in Peru.

Intoxicación aguda con metotrexato usado con fines abortivos: descripión de 2 casos / Acute intoxication with methotrexate, used as an abortive: report of two cases

Acute intoxication with methotrexate, used as an abortive, has not been described in Chile. We report two female patients, aged 15 and 24 years old, who presented with mucositis, erythrodermia, pancytopenia, and elevation of hepatic enzymes. Plasma methotrexate levels confirmed the clinical diagnosis and both patients were treated with high leucovorin doses and management of associated complications. In one patient, pregnancy continued, giving birth to a newborn with cranial, face and limb malformations. The second patient had a late rescue with leucovorin and was discharged with a persistent sensory motor neuropathy. Considering the severity of complications and that patients may deny its use, when there is reasonable clinical suspicion of methotrexate intoxication, leucovorin treatment should be started